In 1993, Fujiki began modeling for the magazine, Men's Non-no. He made his film debut in Hana Yori Dango (1995) as Rui Hanazawa. Fujiki began acting and singing full-time in 1999, after graduating from college in 1997. He has also appeared in several television series, such as Asuka (1999), Love Revolution, Antique (both 2001), Itoshi Kimi e (2004), Gal Circle (2006),Hotaru no Hikari (2007), Around 40: Chumon no Oi Onnatachi (2008), and Last Cinderella (2013). His well known film roles are Game (2003) and Hotaru no Hikari (2012).
Fujiki married his long-time girlfriend on December 27, 2005. They had their first child in December 2006 and their second in May 2010.
|1995||Hana Yori Dango||Rui Hanazawa|
|1996||That's Cunning! Shijousaidai no Sakusen?||Shinobu Ezaki|
|2002||Nurse no Oshigoto the Movie||Kentaro Takasugi|
|2005||Suite -suite-||Hideo Konno|
|2008||Hana Yori Dango Final||Kazu Kaburagi|
|2009||20th Century Boys 2||Shohei Chono|
|Baby! Baby! Baby!||Kenji Takahara|
|20th Century Boys 3||Shohei Chono|
|2010||Gekijouban Trick||Tatsuo Fushimi|
|2012||Hotaru no Hikari||Seiichi Takano|
|2000||Nurse no Oshigoto 3||Kentaro Takasugi|
|Mofuku no Rendezvous||Satoshi Michiki|
|2001||Love Revolution||Eichiro Suga|
|Antique: Seiyo Kotto Yougashiten||Yusuke Ono|
|Nurse no Oshigoto 4||Kentaro Takasugi|
|2003||Koukou Kyoshi||Ikumi Koga|
|Taikoki: Saru to Yobareta Otoko||Oda Nobunaga|
|2004||Itoshi Kimi e||Shunsuke Izumi|
|2005||Slow Dance||Eisuke Serizawa|
|Hoshi ni Negai wo||Kuniaki Takeda|
|1 Litre no Namida||Hiroshi Mizuno|
|2006||Kobayakawa Nobuki no Koi||Kyosuke Nishi|
|2007||1 Litre no Namida Tokubetsu Hen: Tsuioku||Hiroshi Mizuno|
|Operation Love||Tetsuya Tada|
|Hotaru no Hikari||Seiichi Takano|
|2008||Around 40: Chumon no Oi Onnatachi||Keitaro Okamura|
|2009||Ikemen Sobaya Tantei||Juntaro Higuchi|
|Yako no Kaidan||Michio Sayama|
|2010||Saigo no Yakusoku||Shinichiro Okanaka|
|Nakanai to Kimeta hi||Seiji Kirino|
|Hotaru no Hikari 2||Seiichi Takano|
|2011||Control: Hanzai Shinri Sousa||Jun Nagumo|
|Shiawase ni Naro yo||Hidehiko Yashiro|
|Sengyoshufu Tantei: Watashi wa Shadow||Takefumi Asagi|
|2012||Taira no Kiyomori||Saigyo|
|Mikeneko Holmes no Suiri||Hiroshi Katayama|
|Priceless: Aru Wake nee Daro, Namon!||Toichiro Oyashiki|
|2013||Oyari Haishaku: Yoidore Kotoji Tomegaki||Jusaburo Koda|
|Onna Nobunaga||Ieyasu Tokugawa|
|Last Cinderella||Rintaro Tachibana|
|Doctor-X: Gekai Daimon Michiko 2||Shinobu Kondo|
|2014||Yonimo Kimyo na Monogatari||Doctor|
|Sayonara Watashi||Yosuke Hoshino|
|2015||Kokoro ga Pokitto ne||Shin Otake|
|37.5°c no Namida||Chikara Yanagi|
- Before appearing in Hana Yori Dango (1995), he participated in the Non-no model contest with co-stars, Koichi Hashizume and Shosuke Tanihara.
- He met the creator of Boys Over Flowers, Yoko Kamio during the filming of Hana Yori Dango. Kamio has stated that she was glad they choose him, since she saw him in many commercials previously.
- Fujiki appeared alongside Yuki Uchida in Doctor-X: Gekai Daimon Michiko 2.
- Naohito Fujiki went to the first performance of Hana Yori Dango: The Musical and posed for a picture with Jin Shirasu (Rui Hanazawa in the musical).
- Erika Toda also appeared in Gal Circle with Fujiki, which was also his first leading role.