Koji Yamamoto voices Rui in the anime and anime film. In the anime film, Rui is a talented composer with an interest in Tsukushi, a dancer, but harbors romantic feelings for Shizuka, a prima donna.
Rui appears in the mobile app, Hana Yori Dango: F4 and First Kiss as a choice for the player character to date. He first appears in the prologue chapter of the game. As one of the F4, he regularly appears in promotional art for the game. He also had special menu items at the Hana Yori Dango Café, including "Rui Hanazawa Éclair Set" and "Rui Hanazawa Ratatouille".