Sakurako attended Eitoku Academy from kindergarten to first grade. During kindergarten, she developed a crush on Tsukasa Domyoji, who rejected Sakurako because of her looks. Sometime after, she moved with her parents to Germany for her father's job, where she met her friend Thomas. Years later, her parents died in a plane crash and she moved in with her grandparents. Sakurako began living off her inheritance and had plastic surgery done to become attractive.
Sakurako moved back to Japan and transferred back to Eitoku as a freshman.
She appeared in the 1995 Hana Yori Dango film as a minor antagonist portrayed by Kaori Sakagami. The character has some similarities with Sakurako, such as her initial kindness and later jealousy of Tsukushi. However, the character is the leader of the mean girl group and often performs actions close to Yuriko Asai's in the manga. She has also had some plastic surgery.
Megumi Sato portrayed Sakurako in Hana Yori Dango (2005). In the drama, she is in the same class as Tsukushi and takes on Makiko Endo's role for the first few episodes, including angering Tsukasa, which leads to Tsukushi protecting her. Sakurako later reveals that these actions were all calculated. She paid Ryuji to put drugs in Tsukushi's drink and take compromising photos with her. All of this was an attempt to hurt Tsukasa, so she could seduce him, which failed. The character also took a similar action of Junpei Oribe's from the manga, when she kidnaps Tsukushi and has some men beat Tsukasa. Surprisingly, Tsukushi stands up for Sakurako, when Yuriko and her friends found out about her plastic surgery. Sakurako wants to continue being friends with Tsukushi, but also continues pursuing Tsukasa. Later, Sakurako enters the Teen of Japan contest, but loses in the second round. Ayana Moriyama appeared in the fifth episode as a young Sakurako.
Sato returned as Sakurako in a cameo appearance in the first and last episode of Hana Yori Dango Returns (2007). Over voice-over, Tsuskushi explains that Sakurako moved to Australia, after Tsukasa left. While there, she began dating an Australian, who she introduced Tsukushi, when she returned to Japan for a brief visit. In the last episode, Sakurako returns to go to Tsukushi's prom and spends most of her time looking for Tsukasa. She jokingly says "I'm so jealous!" to Tsukushi, when Tsukasa announces their engagement.
In Hana Yori Dango Final (2008), Sato appeared as Sakurako for the last time. Along with many characters from the previous series, Sakurako attends the wedding of Tsukushi and Tsukasa.